Matthew R. Brier, MD, PhD

Washington University in St. Louis
Dr. Matthew R. Brier is an Assistant Professor of Neurology at Washington University in St. Louis. Dr. Brier’s research focuses on the drivers of disability accumulation and neurodegeneration in patients with progressive multiple sclerosis. His lab uses PET and MRI to quantify changes in brain structure and function, aiming to understand how certain aspects of multiple sclerosis pathology escape seemingly efficacious treatment and continue to drive disability. He is particularly interested in the role of metabolic stress and smoldering inflammation. Dr. Brier completed his undergraduate training at the University of Texas at Dallas, followed by MD and PhD training, residency, and fellowship at Washington University in St. Louis.