Date: September 14, 2025
Time: 11:45 am to 12:45 pm
Track: Interactive Lunch Workshop
Peripheral neuropathic pain (PNP), neuropathic pain that arises from damage or disease affecting the peripheral nervous system, is associated with an extremely large disease burden, and there is an increasing and urgent need for new therapies for treating this disorder. One of the most critical issues that prevents consistent, effective translation of preclinical studies to clinical efficacy is that there are fundamental molecular and physiological differences in the biology of neuropathic pain in the rodent models used in preclinical studies and humans. These differences demand that we use human tissues such including human dorsal root ganglia (DRG), skin biopsies and peripheral nerves in pain translational research to improve the translational potential of new therapeutic targets. The talks in this session will review the advances in neuropathic pain research.
At the conclusion of this session, attendees should be able to:
This presentation will discuss novel technologies like single-cell transcriptomics applicable to skin biopsies and the discovery of novel mechanisms of peripheral neuropathic pain.
This presentation details advances in the sensory, affective, and cognitive pathways of pain and emerging strategies engaging them to treat neuropathic pain.
This presentation will discuss single-soma deep RNA sequencing and spatial transcriptomics of human dorsal root ganglia and trigeminal ganglia to study pain and migraine.